Improved mass accuracy for tandem mass spectrometry
نویسندگان
چکیده
منابع مشابه
Liquid Chromatography Tandem Mass/Mass Spectrometry for the Quantification of Fudosteine in Human Serum without Precolumn Derivatization
A quantitative analysis method for fudosteine in human serum by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI/MS/MS) was established, which shows high sensitivity and selectivity. The mobile phase composition was 75% 20 mM acetic acid and 25% acetonitril, which was pumped at a flow rate of 0.40 mL/min. The overall chromatographic run time was ...
متن کاملLiquid Chromatography Tandem Mass/Mass Spectrometry for the Quantification of Fudosteine in Human Serum without Precolumn Derivatization
A quantitative analysis method for fudosteine in human serum by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI/MS/MS) was established, which shows high sensitivity and selectivity. The mobile phase composition was 75% 20 mM acetic acid and 25% acetonitril, which was pumped at a flow rate of 0.40 mL/min. The overall chromatographic run time was ...
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1 Selected tandem mass spectrometry (MS/MS) ion monitoring (SMIM) is the most 2 suitable scanning mode to detect known peptides in complex samples when an ion-trap 3 mass spectrometer is the instrument used for the analysis. In this mode, the MS detector 4 is programmed to perform continuous MS/MS scans on one or more selected 5 precursors, either during a selected time interval, or along the w...
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Tandem mass spectrometry coupled to liquid chromatography (LC-MS/MS) allows identification of proteins in a complex mixture without need for protein purification ("shotgun" proteomics). Recent progress in LC-MS/MS-based quantification, phosphoproteomic analysis, and targeted LC-MS/MS using multiple reaction monitoring (MRM) has made LC-MS/MS a powerful tool for the study of cell physiology.
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ژورنال
عنوان ژورنال: Journal of the American Society for Mass Spectrometry
سال: 2005
ISSN: 1044-0305,1879-1123
DOI: 10.1016/j.jasms.2004.12.005